folinic acidcalcium folinate
How it works
Stabilises the ternary complex of FdUMP with thymidylate synthase, potentiating 5-FU cytotoxicity. Given immediately before 5-FU in FOLFIRINOX / mFFX.
Biochemistry matters: leucovorin must precede 5-FU by a sufficient interval for ternary-complex formation. Verify dose per institutional protocol (eviQ 1512 uses 50 mg; original FFX uses 400 mg/m²).
Dosing
Typical doses
- 400 mg/m² IV over 2 h (standard FFX); eviQ 1512 reduces to 50 mg
Schedule
- D1 of 14-day mFFX cyclecycle_linked
Side Effects
- No direct toxicity at usual doses; occasional rash / allergic reaction